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Leonardo da Vinci’s Hidden Masterpieces: A Revolutionary Vision of Human Anatomy

The secret anatomical studies that anticipated modern cardiology by centuries

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Learning never exhausts the mind.

Leonardo da Vinci

For centuries, Leonardo da Vinci has been celebrated as the ultimate Renaissance polymath, a man whose genius spanned art, architecture, engineering, mathematics, and even anatomy. Yet, his groundbreaking anatomical studies remained hidden from the world for nearly 400 years.

As detailed in Leonardo da Vinci: Anatomist, a book by Martin Clayton, senior curator of the Royal Collection, Leonardo’s anatomical illustrations go far beyond the famous Vitruvian Man. Driven by an insatiable curiosity and a commitment to capturing nature with precision, he conducted meticulous dissections in the hospitals and morgues of Florence. His most extraordinary discovery came in his study of the heart: by injecting melted wax into an ox’s heart and observing the resulting cast, he nearly uncovered the mechanics of blood circulation—centuries ahead of science. His insights into the aortic valve’s function were not fully confirmed until the 1980s.

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A study of a man standing facing the spectator, with legs apart and arms stretched down, drawn as an anatomical figure to show the heart, lungs and main arteries. Royal Collection © Her Majesty Queen Elizabeth II
hree studies, one on a larger scale, of a man’s right arm and shoulder, showing muscles; three studies of a right arm; a diagram to illustrate pronation and supination of the hand. Royal Collection © Her Majesty Queen Elizabeth II

An anatomical study of the principal organs and the arterial system of a female torso, pricked for transfer. Royal Collection © Her Majesty Queen Elizabeth II

Among his most remarkable studies was the dissection of a 100-year-old man, who had claimed to be in perfect health just hours before his death. Leonardo’s post-mortem examination led to the first-ever description of coronary vascular occlusion, a condition now known to be a leading cause of heart disease.

Despite his intention to publish his anatomical drawings in a comprehensive treatise, Leonardo’s death in 1519 left his work buried in obscurity. His notes and sketches remained hidden until the early 1600s, when 600 of them were bound into a single collection and later became part of the Royal Collection.

Large drawing of an embryo within a human uterus with a cow’s placenta; smaller sketch of the same; notes on the subject; illustrative drawings in detail of the placenta and uterus; diagram demonstrating binocular vision; a note on relief in painting and on mechanics. Royal Collection © Her Majesty Queen Elizabeth II
A study of a man’s left leg, stretched forward; beside it, a man’s legs seen from behind; below is a man standing, turned in profile to the left, with his left leg advanced; to the right are two studies of the bones of human left legs and thighs, and one of an animal; with many notes on the muscles. Royal Collection © Her Majesty Queen Elizabeth II

Now, Leonardo da Vinci: Anatomist brings 90 of these revolutionary drawings back to light, offering a rare glimpse into the mind of a man whose scientific brilliance rivaled his artistic mastery. Accompanying the book is a high-resolution iPad app, providing access to 268 pages of his notebooks—an extraordinary testament to Leonardo’s enduring legacy.

A study of the dissection of the lower leg and foot of a bear, viewed in profile to the left. To the left there is also a slight drawing of the leg. Royal Collection © Her Majesty Queen Elizabeth II
Drawing of external genitalia and vagina, with notes; notes on the anal sphincter and diagrams of suggested arrangement of its fibers and its mode of action. Royal Collection © Her Majesty Queen Elizabeth II

Five studies of the bones of the leg and foot; a drawing of the knee joint and patella; two studies of the bones of a right leg with the knee flexed; the muscles of a right buttock, thigh and calf. Royal Collection © Her Majesty Queen Elizabeth II
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